Association between fluid intake and kidney function, and survival outcomes analysis: a nationwide population-based study

作者：Wu Li Wei; Chen Wei Liang; Liaw Fang Yih; Sun Yu Shan; Yang Hui Fang; Wang Chung Ching; Lin Chien Ming; Tsao Yu Tzu^*

来源：BMJ Open, 2016, 6(5): e010708.

DOI：10.1136/bmjopen-2015-010708

• fluid intake
• all-cause mortality
• cardiovascular mortality

Objectives Fluid intake, one of the most common daily activities, has not been well studied in chronic kidney disease (CKD) populations, and clinical outcomes are rarely addressed. The aim of this nationwide study is to explore the influence of daily fluid intake on cardiovascular and all-cause mortality and its association with renal function.
Design Observational cohort study.
Participants In all, 2182 participants aged more than 20years participated in the Third National Health and Nutrition Examination Survey (1988-1994).
Main outcome measures Survival outcomes in patients with or without CKD, using multiple variable adjusted Cox proportional hazard models.
Results In a longitudinal survey with a median follow-up length of 15.4years, 1080 participants died and 473 cardiovascular deaths were recorded. For all-cause mortality in the CKD group, individuals in the highest quartile of fluid intake (3.576L/day) had better survival outcomes than those in the lowest quartile of fluid intake (2.147L/day) (p=0.029) after adjustment of several pertinent variables.
Conclusions Although the interpretation of this observational study was limited by the failure to identify the compositions of ingested fluids, adequate hydration may offer some advantages in patients with CKD. However, the underlying pathophysiological mechanisms of the responses of normal and injured kidneys to chronic changes in fluid consumption warrant further investigation.

• 出版日期2016
• 单位河北医科大学