Antioxidant rich diet supplements ( Spirulina and tamarind fruit pulp) mitigate hematological disorders in fluoride exposed mice

作者：Sharma Shweta; Yadav Nirmala; Pandey Anil; Sharma Subhasini; Sharma K P

来源：Toxicological and Environmental Chemistry, 2013, 95(10): 1739-1747.

DOI：10.1080/02772248.2014.907409

• fluoride
• hematology
• Spirulina
• Swiss albino mice
• tamarind

The effect of antioxidant rich diet supplements of Spirulina and tamarind fruit pulp at 230mg kg(-1) body weight, separately as well as in combination, on various hematological parameters of Swiss albino mice exposed to fluoride for seven days at daily doses of 190mg kg(-1) body weight and for 90days at daily doses of 94mg kg(-1) body weight is reported. Compared with controls, fluoride exposure decreased erythrocyte (12%-18%), leukocyte (16%) and platelet counts (7%, only for short-term exposure), hemoglobin (2%-17%) and packed cell volume (2%-14%) in Swiss albino mice reared on standard feed but these were altered little in the diet supplement groups. Fluoride exposure decreased lymphocytes in both standard feed (16%-21%) and diet supplement groups (5%-19%, but only after long-term exposure). Fluoride withdrawal led to recovery of the post-treated mice from long-term exposure. Spirulina alone and also in combination with tamarind fruit pulp was found more effective than tamarind alone in reducing hematological disorders in fluoride treated mice.

• 出版日期2013-12-1