Alpha (1,2)-Fucosyltransferase M307A Polymorphism Improves Piglet Survival

作者：Kim Kyungtae; Dinh Truong Nguyen; Choi Minkyung; Kim Jin Hoi; Seo Han Geuk; Dadi Hailu; Cha Se Yeoun; Seo Kunho; Lee Yun Mi; Kim Jong Joo; Park Chankyu^*

来源：Animal Biotechnology, 2013, 24(3): 243-250.

DOI：10.1080/10495398.2013.776964

• Disease resistance
• FUT1
• Piglet survival
• Swine

To confirm the beneficial effects of alpha (1,2)-fucosyltransferase (FUT1) M307(A) on piglet survival on commercial farms, we performed PCR-RFLP analysis of FUT1 M307 in successfully marketed (n=245) and disease affected/deceased pigs during weaning (n=252) at a commercial farm. We also evaluated the FUT1 genotypes of 190 healthy pigs from three different genetic backgrounds. The distribution of genotypes differed between the successfully marketed and disease affected/deceased pig groups. The frequency of the A allele, associated with resistance to edema and post-weaning diarrhea, was higher in the post-weaning survival group (0.21) than in the non-survival group (0.16, P%26lt;0.05). The odds ratio for piglet survival between AA and GG genotypes was 1.98; thus, piglet survival for individuals with the AA genotype was almost two-fold greater than for GG individuals. The FUT1 gene polymorphism can be used as an effective marker for selection programs to improve post-weaning piglet survival.

• 出版日期2013-7-1