New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia

作者：Brandimarte Lucia; Pierini Valentina; Di Giacomo Danika; Borga Chiara; Nozza Filomena; Gorello Paolo; Giordan Marco; Cazzaniga Giovanni; te Kronnie Geertruy; La Starza Roberta; Mecucci Cristina^*

来源：Blood, 2013, 121(25): 5064-5067.

DOI：10.1182/blood-2013-02-487256

The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific leukemic fusions generated from recurrent 11q23 and 11q14 chromosome translocations. Deep sequencing recently identified NAP1L1/12q21 as another MLLT10 partner in T-cell acute lymphoblastic leukemia (T-ALL). In pediatric T-ALL, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. Gene expression profile signatures of the HNRNPH1- and DDX3X-MLLT10 fusions placed them in the HOXA subgroup. Remarkably, they were highly similar only to PICALM-MLLT10-positive cases. The present study showed MLLT10 promiscuity in pediatric T-ALL and identified a specific MLLT10 signature within the HOXA subgroup.

• 出版日期2013-6-20