ADAPTATION FACTORS OF BORRELIA FOR HOST AND VECTOR

作者：Skotarczak Bogumila^*

来源：Annals of Agricultural and Environmental Medicine, 2009, 16(1): 1-8.

• genome and adaptation of metabolism of Borrelia burgdorferi
• quorum sensing
• Osp proteins
• Erp and CRASP proteins
• vls gene

The life transmission cycle of B. burgdoiferi requires migration of spirochetes from tick's gut to its salivary glands during vertebrate's blood sucking, penetrating to the vertebrate's tissues and their colonization. A special feature of these bacteria. despite its relatively small genome, is the ability to adapt ill different host environments. These unusual properties of borreliae are associated with large number of plasmids, which show a high variability as a result of recombination with each other. Changes in the synthesis of outer proteins are the first strategy of borreliae ill avoiding the destructive effect of, the host's immune system. Then, by colonizing tissues, they initiate production of Erp and CRASP proteins, which bind regulators aid components of complement and repress the cytolytic effect of the host's serum. Some evidences indicate that the spirochetes use quorum sensing as a mechanism to control protein expression. B. burgdorferi probably utilized a LuxS/autoinducer-2-dependent quorum sensing mechanism, However, it is not yet known how B. burgdoiferi detect Al-2. Analysis of the results of expression studies Of the luxS gene shows that the molecular mechanisms of this phenomenon ill B. burgdorderi are only fragmentarily known. Continuation of quorum sensing studies may he essential ill improving the construction of vaccines,is well as therapy of Lyme disease.

• 出版日期2009-6