A Micellar Catalysis Strategy for Amidation of Alkynyl Bromides: Synthesis of Ynamides in Water

作者:Yang, Yunqin; Meng, Xiangtai; Zhu, Baolong; Jia, Ying; Cao, Xiaoji; Huang, Shenlin*
来源:European Journal of Organic Chemistry, 2019, 2019(5): 1166-1169.
DOI:10.1002/ejoc.201801601

摘要

Copper-catalyzed amidation of alkynyl bromides can be carried out in water for the first time, which is made possible by a micellar catalysis strategy using rosin-based surfactant APGS-550-M. The surfactant can be easily prepared from natural abundant biomass, resin acids. Studies as to substrate scope and reaction aqueous medium recycling showcase the ease and sustainability of this technology.