A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data

作者：Broom Bradley M^*; Ryan Michael C; Brown Robert E; Ikeda Futa; Stucky Mark; Kane David W; Melott James; Wakefield Chris; Casasent Tod D; Akbani Rehan; Weinstein John N^*

来源：Cancer Research, 2017, 77(21): E23-E26.

DOI：10.1158/0008-5472.CAN-17-0318

Clustered heatmaps are the most frequently used graphics for visualization of molecular profiling data in biology. However, they are generally rendered as static, or only modestly interactive, images. We have now used recent advances in web technologies to produce interactive "next-generation" clustered heatmaps (NG-CHM) that enable extreme zooming and navigation without loss of resolution. NG-CHMs also provide link-outs to additional information sources and include other features that facilitate deep exploration of the biology behind the image. Here, we describe an implementation of the NG-CHM system in the Galaxy bioinformatics platform. Weillustrate the algorithm and available computational tool using RNA-seq data from The Cancer Genome Atlas program's Kidney Clear Cell Carcinoma project.

• 出版日期2017-11-1