Study of gastro-oesophageal reflux disease in patients with mild-to-moderate chronic obstructive pulmonary disease in India

作者：Kamble Nitish L; Khan Naushad A; Kumar Naresh; Nayak Hemanta K; Daga Mradul K^*

来源：Respirology, 2013, 18(3): 463-467.

DOI：10.1111/j.1440-1843.2012.02285.x

• 24-h pH monitoring
• chronic obstructive pulmonary disease
• distal gastro-oesophageal reflux disease
• gastro-oesophageal reflux disease
• proximal gastro-oesophageal reflux disease

Background and objective: To study the incidence and pattern of gastro-oesophageal reflux disease (GORD) in patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) using dual-probe 24-h oesophageal pH recording.
Methods: This was a prospective study of 50 patients with mild-to-moderate stage COPD based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. A detailed history of illness along with spirometry was done in all patients. In the study group, reflux symptoms were measured using a validated scoring system. All the patients underwent oesophageal manometry and dual-probe 24-h oesophageal pH recording.
Results: Symptoms of gastro-oesophageal reflux were present in 38 patients. Twenty-four-hour oesophageal pH monitoring revealed pathological reflux in 31 out of 38 symptomatic and 8 out of 12 asymptomatic patients. The overall rate of GORD was 78% in our study. Only distal GORD was observed in 11 (28.9%), and both distal and proximal GORD was observed in 20 (52.6%) out of the 38 symptomatic subjects. In the remaining 12 asymptomatic patients, eight had GORD. Distal GORD was present in six (50%) patients, and two (16.6%) had both distal and proximal GORD in this group. Isolated proximal GORD was not observed in any patient.
Conclusions: There is an increased occurrence of GORD in patients with even mild-to-moderate COPD.

• 出版日期2013-4