Aberrant expression of tumor-associated carbohydrate antigen Globo H in thyroid carcinoma

作者：Cheng Shih Ping; Yang Po Sheng; Chien Ming Nan; Chen Ming Jen; Lee Jie Jen; Liu Chien Liang

来源：Journal of Surgical Oncology, 2016, 114(7): 853-858.

DOI：10.1002/jso.24479

• Globo H
• thyroid cancer
• tumor-associated carbohydrate antigen

Background and ObjectivesThe induction of tumor-associated carbohydrate antigen results from altered glycosylation in transformed cells. Globo H is a hexasaccharide glycosphingolipid overexpressed on malignancies of epithelial origin and has become an attractive vaccine target. We aimed to investigate the expression patterns and prognostic value of Globo H in thyroid neoplasms.
MethodsGlobo H expression was examined by immunohistochemical analysis using commercial and in-house tissue microarrays. The expression was correlated with clinicopathologic characteristics in papillary thyroid cancer.
ResultsNormal or benign thyroid lesions were negative for Globo H expression. Globo H was positive in 33% medullary, 24% papillary, 11% undifferentiated, and 8% follicular thyroid cancer. Globo H expression in papillary thyroid cancer was associated with extrathyroidal invasion (P=0.017), BRAF mutation (P=0.010), AMES high risk (P=0.045), and increased ATA risk of recurrence (P=0.022).
ConclusionsGlobo H is specifically expressed in a subset of thyroid malignancies. In papillary thyroid cancer, Globo H expression is associated with invasiveness and BRAF mutation. Immunotherapy targeting Globo H may have potential applications in thyroid cancer. J. Surg. Oncol. 2016;114:853-858.

• 出版日期2016-12-1
• 单位河北医科大学