Bismuth nitrate-catalyzed multicomponent reaction for efficient and one-pot synthesis of densely functionalized piperidine scaffolds at room temperature

作者：Brahmachari Goutam^*; Das Suvankar

来源：Tetrahedron Letters, 2012, 53(12): 1479-1484.

DOI：10.1016/j.tetlet.2012.01.042

• Bi(NO3)(3)center dot 5H(2)O
• Heterocycles
• Highly functionalized piperidines
• One-pot synthesis
• Tandem reaction
• Multicomponent reaction
• Room temperature
• Environmentally benign

A simple, straightforward, and highly efficient diastereoselective multicomponent one-pot synthesis of a series of pharmaceutically interesting functionalized piperidine derivatives has been developed based on a low-cost and environmentally benign Bi(NO3)(3)center dot 5H(2)O catalyst via tandem reactions of 1,3-dicarbonyl compounds, aromatic aldehydes, and various amines in ethanol at room temperature. High atom-economy, good yields, eco-friendliness, and mild reaction conditions are some of the important features of this protocol.

• 出版日期2012-3-21