Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: a matched-pair analysis

作者：Ishiyama K^*; Takami A; Kanda Y; Nakao S; Hidaka M; Maeda T; Naoe T; Taniguchi S; Kawa K; Nagamura T; Atsuta Y; Sakamaki H

来源：Leukemia, 2012, 26(3): 461-464.

DOI：10.1038/leu.2011.229

• allogeneic hematopoietic stem cell transplantation
• acute myeloid leukemia
• unfavorable cytogenetic risk
• t(6
• 9)(p23
• q34)

Acute myeloid leukemia (AML) with t(6;9)(p23;q34) is well known to have a poor prognosis treated with chemotherapy and autotransplantation. The presence of this karyotype is an indicator for allogeneic hematopoietic stem cell transplantation (HSCT); however, the impact of t(6; 9)(p23; q34) on the HSCT outcome remains unclear. We conducted a matched-pair analysis of de novo AML patients with and without t(6; 9)(p23; q34) using data obtained from the Japanese HSCT data registry. A total of 57 patients with t(6; 9)(p23; q34) received transplants between 1996 and 2007, and 171 of 2056 normal karyotype patients matched for age, disease status at HSCT and graft source were selected. The overall survival, disease-free survival, cumulative incidence of relapse and the non-relapse mortality in t(6; 9)(p23; q34) patients were comparable to those for normal karyotype patients. A univariate analysis showed that t(6; 9)(p23; q34) had no significant impact on the overall survival. These findings suggest that allogeneic HSCT may overcome the unfavorable impact of t(6; 9)(p23; q34) as an independent prognostic factor. Leukemia (2012) 26, 461-464; doi:10.1038/leu.2011.229; published online 26 August 2011

• 出版日期2012-3
• 单位河北医科大学