Genetic support and diversity of acquired extended-spectrum beta-lactamases in Gram-negative rods

作者：Poirel Laurent; Bonnin Remy A; Nordmann Patrice^*

来源：Infection, Genetics and Evolution, 2012, 12(5): 883-893.

DOI：10.1016/j.meegid.2012.02.008

• beta-Lactamases
• Integron
• Transposon
• Insertion sequence
• ESBL

Genes encoding extended-spectrum beta-lactamases (ESBLs) have been reported in a variety of Gram-negative species, mostly in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. They are either TEM- or SHV-derivatives, CTX-M-like enzymes and less frequently of the GES, PER, or VEB types. The mechanisms at the origin of their acquisition are diverse, and mostly are related to insertion sequences, transposons and class 1 integrons. This diversity of genetic vehicles at the origin of these mobilization/acquisition processes may explain spread of ESBLs worldwide.

• 出版日期2012-7