科研之友
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摘要
A metal-free regio- and stereoselective method is achieved for the preparation of (E)-configured alpha-halo enamides, vinyl thioethers, and vinyl ethers using aqueous HX (X = F, Cl, Br, I), which features high functional group compatibility and regio- and stereoselectivity, mild conditions, high efficiency, and rapid transformation. Additionally, the isomers could be yielded readily from the (E)-configured a halo enamides via photocatalysis or under Sonogashira coupling conditions.
