Altered T-bet Dominance in IFN-gamma-Decoupled CD4(+) T Cells with Attenuated Cytokine Storm and Preserved Memory in Influenza

作者：Dutta Avijit; Miaw Shi Chuen; Yu Jhang Sian; Chen Tse Ching; Lin Chun Yen; Lin Yung Chang; Chang Chia Shiang; He Yueh Chia; Chuang Sheng Hao; Yen Ming I; Huang Ching Tai^*

来源：The Journal of Immunology, 2013, 190(8): 4205-4214.

DOI：10.4049/jimmunol.1202434

Cytokine storm has been postulated as one of the major causes of mortality in patients with severe respiratory viral infections such as influenza. With the help of an influenza Ag-specific mouse experimental system, we report that CD4(+) T cells contribute effector cytokines leading to lung inflammation in acute influenza. Although virus can no longer be detected from tissues 14 d post-infection, virus-derived Ag continues to drive a CD4(+) T cell response after viral clearance. Ag-specific CD4(+) T cells proliferate and evolve into memory CD4(+) T cells efficiently, but the production of effector cytokines is seriously hampered during this phase. This decoupling of proliferation and effector cytokine production doesn%26apos;t appear in conjunction with increased suppression by regulatory T cells or decreased induction of transcription factors. Rather, GATA-3 and ROR-gamma t levels are elevated when compared with cells that have effector cytokine production. T-bet dominance over GATA-3 and ROR-gamma t decreases with the disarmament of effector cytokine production. Importantly, upon reinfection, these decoupled cells produce elevated levels of IFN-gamma and were effective in virus eradication. These results provide a mechanism through altered T-bet dominance to dampen the cytokine storm without impeding the generation of memory T cells in influenza virus infection. The Journal of Immunology, 2013, 190: 4205-4214.

• 出版日期2013-4-15
• 单位长春大学