科研之友
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摘要
Background: Measurements in the neurosciences are afflicted with observational noise. Granger-causality inference typically does not take this effect into account. We demonstrate that this leads to false positives conclusions and spurious causalities. New method: State space modelling provides a convenient framework to obtain reliable estimates for Granger-causality. Despite its previous application in several studies, the analytical derivation of the statistics for parameter estimation in the state space model was missing. This prevented a rigorous evaluation of the results. Results: In this manuscript we derive the statistics for parameter estimation in the state space model. We demonstrate in an extensive simulation study that our novel approach outperforms standard approaches and avoids false positive conclusions about Granger-causality. Comparison with existing methods: In comparison with the naive application of Granger-causality inference, we demonstrate the superiority of our novel approach. The wide-spread applicability of our procedure provides a statistical framework for future studies. The application to mice electroencephalogram data demonstrates the immediate applicability of our approach. Conclusions: The analytical derivation of the statistics presented in this manuscript enables a rigorous evaluation of the results of Granger causal network inference. It is noteworthy that the statistics can be readily applied to various measures for Granger causality and other approaches that are based on vector autoregressive models.
- 出版日期2015-1-15
- 单位河北医科大学
