Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites

作者：Wright Amy E^*; Killday K Brian; Chakrabarti Debopam; Guzman Esther A; Harmody Dedra; McCarthy Peter J; Pitts Tara; Pomponi Shirley A; Reed John K; Roberts Bracken F; Felix Carolina Rodrigues; Rohde Kyle H

来源：Marine Drugs, 2017, 15(1): 16.

DOI：10.3390/md15010016

• bis(indole) alkaloid
• Spongosorites
• antibacterial
• pancreatic cancer

A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.

• 出版日期2017-1