Development and evaluation of tetrapod-shaped granular artificial bones

作者：Choi Sungjin^*; Liu I Ii; Yamamoto Kenichi; Igawa Kazuyo; Mochizuki Manabu; Sakai Takamasa; Echigo Ryosuke; Honnami Muneki; Suzuki Shigeki; Chung Ung il; Sasaki Nobuo

来源：Acta Biomaterialia, 2012, 8(6): 2340-2347.

DOI：10.1016/j.actbio.2012.02.019

• Bone graft
• Calcium phosphate
• Intergranular pores
• Mechanical properties
• Tetrapod

We have developed a novel form of granular artificial bone "Tetrabones" with a homogeneous tetrapod shape and uniform size. Tetrabones are four armed structures that accumulate to form the intergranular pores that allow invasion of cells and blood vessels. In this study we evaluated the physicochemical characteristics of Tetrabones in vitro, and compared their biological and biomechanical properties in vivo to those of conventional beta-tricalcium phosphate (beta-TCP) granule artificial bone. Both the rupture strength and elastic modulus of Tetrabone particles were higher than those of beta-TCP granules in vitro. The connectivity of intergranular pores 100, 300, and 400 pm in size were higher in Tetrabones than in the beta-TCP granules. Tetrabones showed similar osteoconductivity and biomechanical stiffness to beta-TCP at 2 months after implantation in an in vivo study of canine bone defects. These results suggest that Tetrabones may be a good bone graft material in bone reconstruction.

• 出版日期2012-7