An Efficient Protocol for the Synthesis of 3,4-Dihydropyrimidine-2-(1H)-ones Catalyzed by Functionalized Ionic Liquid [DDPA][HSO4]

作者：Liu Xiaobing; Lu Ming^*; Lu Tingting

来源：Chiang Mai Journal of Science, 2011, 38(2): 263-269.

• 3,4-dihydropyrimidine-2-(1H)-one
• Biginelli reaction
• ionic liquid
• catalyst

An environmentally benign aqueous Biginelli protocol for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones (DHPMs) using a functionalized ionic liquid, 3-(N,N-dimethyldodecylammonium) propanesulfonic acid hydrogen sulfate ([DDPA][HSO4]) as a catalyst has been achieved. High yields of the products, short reaction times, mild reaction conditions and simple experimental procedure make this protocol complementary to the existing methods. The catalyst can be reused without obvious loss of the catalytic activity.

• 出版日期2011-4
• 单位南京理工大学