A bifunctional chelator featuring the DOTAM-Gly-L-Phe-OH structural subunit: en route toward homo- and heterobimetallic lanthanide(III) complexes as PARACEST MRI contrast agents

作者：Suchy Mojmir; Li Alex X; Bartha Robert; Hudson Robert H E^*

来源：Tetrahedron Letters, 2010, 51(7): 1087-1090.

DOI：10.1016/j.tetlet.2009.12.086

• DOTAM-Gly-L-Phe-OH
• DO3A
• HBTU
• Lanthanides
• PARACEST

A new synthesis of a bifunctional chelator possessing DOTAM-Gly-L-Phe-OH and DO3A chelating cages interconnected by an oligoamide chain has been achieved via HBTU-mediated coupling from easily accessible building blocks. Both homo- and heterobimetallic lanthanide(III) complexes derived from this bifunctional chelator have been prepared in moderate yields. The CEST spectrum acquired for homobimetallic Eu(3+) complex showed this molecule to be a promising PARACEST MRI contrast agent whereas the Eu(3+)/Tm(3+) heterobimetallic complex lacked a useful CEST signal.

• 出版日期2010-2-17