An Aurone-derived Low-molecular-weight Fluorescence Probe for the Detection of Hg2+ in Aqueous Solution and Living Cells

作者:Zhang, Min*; Bao, Yong-Tuan; Yang, Wenbo; Xiao, Hui-Feng; Han, Zhi-Xiang; Wu, Xiangyang; Yang, Liuqing*
来源:Journal of Heterocyclic Chemistry, 2018, 55(5): 1130-1135.
DOI:10.1002/jhet.3143

摘要

A low-molecular-weight fluorescent probe 1 (M.W.=238.24) based on aurone was synthesized, and its application in fluorescent detection of Hg2+ in aqueous solution and living cells was reported. It exhibited an on-off fluorescent response toward Hg2+ in aqueous solution. Both the color and fluorescence changes of the probe were remarkably specific for Hg2+ in the presence of other common metal ions, satisfying the selective requirements for biomedical and environmental monitoring application. The probe has been applied in direct measurement of Hg2+ content in river water samples and imaging of Hg2+ in living cells, which further indicates the potential application values in environmental and biological systems.