Ag2CO3/CA-AA-AmidPhos Multifunctional Catalysis in the Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides

作者：Wang, Haifei^*; Deng, Qifu; Zhou, Zhipeng; Hu, Shunqin; Liu, Zhiguo; Zhou, Li-Yi

来源：Organic Letters, 2016, 18(3): 404-407.

DOI：10.1021/acs.orglett.5b03430

• ASYMMETRIC 3+2 CYCLOADDITION
• CHIRAL CALCIUM COMPLEXES
• IMINO ESTERS
• NITROALKENES
• DERIVATIVES
• GLYCINE
• 1,4-ADDITION
• PYRROLIDINES
• REVERSAL
• LIGANDS

The new Ag2CO3/CA-AA-amidphos complexes have been demonstrated as highly efficient multifunctional catalysts in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides. Under optimal conditions, highly functionalized endo-4 pyrrolidines were obtained with excellent yields (up to 99% yield) and enantioselectivities (up to 96% ee).

• 出版日期2016-2-5
• 单位湖南工业大学