A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade

作者：Jose A^*; Cramer A K; Davar K; Gutierrez G

来源：Lupus, 2017, 26(3): 316-319.

DOI：10.1177/0961203316657435

• Systemic lupus erythematosus
• cardiovascular disease
• TMP
• SMX
• drug-induced lupus erythematosus

We report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short course of corticosteroids with complete resolution of symptoms. To our knowledge this is the first reported case of TMP/SMX-induced DILE presenting with life-threatening serositis. When confronted with sterile exudative effusions, clinicians should strongly consider non-infectious etiologies.

• 出版日期2017-3