An efficient and practical synthesis of antibacterial linezolid

作者:Zhang, Xingxian*; Chen, Wei; Li, Cheng; Wu, Xiang
来源:Journal of Chemical Research-S, 2009, (12): 739-740.
DOI:10.3184/030823409X12590575888607

摘要

A convergent and efficient synthesis of linezolid was developed using the cycloaddition of commercially available (R)-epichlorohydrin with morpholine substituted phenylisocyanate catalysed by MgI(2) or MgBr(2) etherate as the key step in the 50% overall yield.

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