Asymmetric synthesis of naproxen

作者：Hu, AX^*; Guo, CC; Fan, GZ

来源：Acta Chimica Sinica, 2000, 58(1): 100-104.

• naproxen
• (2R, 3R) - dimethyl tartrate
• DBDMH
• asymmetric bromination
• rearrangement

Naproxen was synthesized from 2 - methoxynaphthalene, using (2R,3R) - dimethyl tartrate as chiral auxiliary, DBDMH and Br-2 as brominating agent, KH2PO4 as rearrangement agent, 10% Pd - C/ HCO2NH4 as catalytic transfer hydrogenolytic agent via propionylization, asymmetric bromination, hydrolysis, rearrangement and catalytic transfer hydrogenolysis. Totalyield Tvas 44% (based on 2 - methoxynaphthalene) with the e.e.value of product being 94%.

• 出版日期2000
• 单位湖南大学