A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

作者：Hwang Ye Jin; Coley Connor W; Abolhasani Milad; Marzinzik Andreas L; Koch Guido; Spanka Carsten; Lehmann Hansjoerg; Jensen Klavs F^*

来源：Chemical communications, 2017, 53(49): 6649-6652.

DOI：10.1039/c7cc03584e

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 mu L. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

• 出版日期2017-6-21
• 单位MIT