A novel and convenient synthesis of 3-amino-2H-1,2,4-triazoles from isoselenocyanates and hydrazine hydrate

作者：Li, Xue^*; Peng, Zhixiang; Zhang, Yuanyuan; Wang, Jiangwei; Gan, Bin; Xie, Yuanyuan

来源：Journal of Chemical Research, 2018, 42(5): 255-259.

DOI：10.3184/174751918X15260518865352

• isoselenocyanates
• selenoureas
• hydrazine hydrate
• 3-amino-2H-1,2,4-triazoles

A novel and convenient one-pot synthesis of 3-amino-2H-1,2,4-triazoles from two molecules of isoselenocyanates and hydrazine hydrate via cyclodeselenisation was developed. Various 3-amino-2H-1,2,4-triazoles were obtained in moderate to good yields (33-45%, based on isoselenocyanates). The selenium powder and aromatic amine side products during the reaction could be recycled for efficient preparation of isoselenocyanates, which improved the atom economy. A plausible mechanism was proposed for the formation of the target products.

• 出版日期2018-6
• 单位浙江工业大学