A simplified three-times weekly daptomycin dosing regimen for chronic hemodialysis patients

作者：Burkhardt Olaf; Kielstein Jan T^*

来源：Expert Review of Anti-Infective Therapy, 2010, 8(1): 11-14.

DOI：10.1586/ERI.09.121

• daptomycin
• dialysis
• end-stage renal disease
• infection
• pharmacokinetics

Approximately 2.3 million patients worldwide are undergoing chronic renal replacement therapy. In that population, acute infections substantially contribute to the excessive morbidity and mortality. The risk for invasive methicillin-resistant Staphylococcus aureus infections in this population is approximately 100-fold higher than in the general population, therefore dialysis patients currently account for up to approximately 15% of all invasive methicillin-resistant Staphylococcus aureus infections. A simplified three-times weekly dosing regimen for hemodialysis patients now allows for practical, hassle-free and effective treatment with claptomycin, which is licensed for the treatment of complicated skin and soft tissue infections, including resistant strains of Staphylococcus aureus and life-threatening Gram-positive infections, vancomycin-resistant enterococcal infections and right-sided endocarditis.

• 出版日期2010-1