Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

作者：Mohapatra Swapna S; Wilson Zoe E; Roy Sujit; Ley Steven V^*

来源：Tetrahedron, 2017, 73(14): 1812-1819.

DOI：10.1016/j.tet.2017.02.026

• Alkylation
• Scandium triflate
• Bis(indolyl)methanes
• Flow
• Catalysis

Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)(3) catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.

• 出版日期2017-4-6