Artificial nutrition dependence after cetuximab versus cisplatin combined with radiotherapy for advanced head and neck cancer: A propensity score-matched analysis

作者：Ishimaru Miho; Ono Sachiko; Suzuki Sayaka; Matsui Hiroki; Fushimi Kiyohide; Yasunaga Hideo

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2017, 39(2): 320-325.

DOI：10.1002/hed.24583

• head and neck neoplasms
• cetuximab
• chemoradiotherapy
• enteral nutrition
• parenteral nutrition

Background. The purpose of this study was to compare the effect of cetuximab-based radiotherapy (RT) with cisplatin-based concomitant chemoradiotherapy (CCRT) on artificial nutrition dependence in locoregional advanced head and neck cancer.
Methods. We identified patients treated with cetuximab-based RT or CCRT between 2012 and 2014 in a Japanese national database, and used propensity score-matched analyses to evaluate artificial nutrition dependence for 30 days after starting chemotherapy and at hospital discharge.
Results. Of 3935 eligible patients, propensity score matching generated 250 pairs. Thirty-day artificial nutrition dependence was significantly lower in the cetuximab-based RT group than in the CCRT group (25.6% vs 35.2%; odds ratio [OR] -0.67; 95% confidence interval [CI] - 0.46-0.97; p = .036). No significant difference in artificial nutrition dependence at hospital discharge was shown ( 6.2% vs 7.2%; OR 5 1.07; 95% Cl = 0.52-2.17; p = .861). Difference in duration of hospitalization was insignificant.
Conclusion. Cetuximab-based RT may reduce short-term artificial nutrition dependence compared to CCRT.

• 出版日期2017-2