科研之友
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摘要
Construction of all-carbon quaternary stereocenter by asymmetric Friedel-Crafts alkylation reaction remains a significant challenge. By the introduction of CF3 group at the -position of nitroalkene, a highly enantioselective Friedel-Crafts reaction of indoles with -CF3--substituted nitroalkenes was achieved using Ni(ClO4)(2)-bisoxazoline complex as a catalyst, which afforded indole-bearing chiral compounds with trifluoromethylated all-carbon quaternary stereogenic centers in good yields and excellent enantioselectivities.
- 出版日期2014-3-3
- 单位浙江工业大学
