Deoxyribonucleic Acid Mediated Heterogeneous Integration of Micro- and Nanoscale Devices

作者：Yesudas Joshy P; Olsen Trevor; Ng Jason; Kovalenko Andriy; Dew Steven K^*

来源：Journal of Nanoscience and Nanotechnology, 2016, 16(7): 7301-7313.

DOI：10.1166/jnn.2016.11605

• DNA Assisted Self-Assembly
• Heterogeneous Integration
• Nanoscale Devices
• Biotin-Avidin
• Surface Functionalization

We present an approach for the integration of micro- and nanoscale components using self-assembly based on the specific binding of complementary DNA strands. In this concept, separately fabricated components are integrated onto a common substrate in the proper location based on this molecular recognition in solution, rather than robotic mechanical positioning. In an attempt to demonstrate this, we have fabricated model devices based on small (25 mu m) silicon tiles which have been functionalized with a 16 base strand of DNA. The complementary DNA strand has been attached to a patterned silicon substrate. Two different DNA attachment strategies are presented based on bare silicon or on employing a gold coating. Validation of the DNA attachment procedure is demonstrated using contact angle measurement, X-ray photoelectron spectroscopy, fluorescent microscopy and time-of-flight secondary mass spectrometry. While viable DNA functionalization of the surface has been demonstrated, assembly of the 25 mu m devices has proven to be challenging. Possible reasons for this are presented. Somewhat more success has been achieved using 200 nm gold nanoparticles or by employing an biotin-avidin based binding procedure.

• 出版日期2016-7
• 单位Saskatchewan