A flexible and highly sensitive nonenzymatic glucose sensor based on DVD-laser scribed graphene substrate

作者：Lin, Songyue; Feng, Wendou; Miao, Xiaofei; Zhang, Xiangxin; Chen, Sujing; Chen, Yuanqiang; Wang, Wei^*; Zhang, Yining^*

来源：Biosensors and Bioelectronics, 2018, 110: 89-96.

DOI：10.1016/j.bios.2018.03.019

• Laser-scribed graphene
• Copper nanoparticles
• Electrodeposition
• Flexible conductive substrates
• Glucose sensor
• Flexible biosensors

Flexible and implantable glucose biosensors are emerging technologies for continuous monitoring of blood glucose of diabetes. Developing a flexible conductive substrates with high active surface area is critical for advancing the technology. Here, we successfully fabricate a flexible and highly sensitive nonenzymatic glucose by using DVD-laser scribed graphene (LSG) as a flexible conductively substrate. Copper nanoparticles (Cu-NPs) are electrodeposited as the catalyst. The LSG/Cu-NPs sensor demonstrates excellent catalytic activity toward glucose oxidation and exhibits a linear glucose detection range from 1 mu M to 4.54 mM with high sensitivity (1.518 mA mM(-1)cm(-2)) and low limit of detection (0.35 01). Moreover, the LSG/Cu-NPs sensor shows excellent reproducibility and long-term stability. It is also highly selective toward glucose oxidation under the presence of various interfering species. Excellent flexing stability is also demonstrated by the LSG/Cu-NPs sensor, which is capable of maintaining 83.9% of its initial current after being bent against a 4-mm diameter rod for 180 times. The LSG/Cu-NPs sensor shows great potential for practical application as a nonenzymatic glucose biosensor. Meanwhile, the LSG conductive substrate provides a platform for the developing next-generation flexible and potentially implantable bioelectronics and biosensors.

• 出版日期2018-7-1
• 单位中国科学院福建物质结构研究所; 中国科学院大学