Hyaluronan oligosaccharides promote diabetic wound healing by increasing angiogenesis

作者：Wang, Yi; Han, Guanying^*; Guo, Bin; Huang, Jianhua^*

来源：Pharmacological Reports, 2016, 68(6): 1126-1132.

DOI：10.1016/j.pharep.2016.07.001

• Hyaluronan oligosaccharides
• Diabetic wound healing
• Angiogenesis

Background: Hyaluronan (also known as hyaluronic acid) oligosaccharides (O-HA) can promote angiogenesis and wound healing; however, there are few reports on whether O-HA also plays a role in healing wounds of diabetic patients. @@@ Methods: In this study, we prepared a special ointment containing a mixture of hyaluronan fragments from 2 to 10 disaccharide units and investigated its effects on healing the wounds of diabetic rats. @@@ Results: We found that O-HA significantly increases proliferation, migration, and tube formation of endothelial cells under high glucose conditions, and topical administration of O-HA ointment promotes wound healing by increasing angiogenesis in the wounded area of the skin. The underlying mechanisms are that O-HA increases the phosphorylation of Src and ERK, and expression of TGF beta1, thereby increasing angiogenesis. @@@ Conclusions: This suggests that topical application of O-HA could be a useful method by which to treat diabetic wounds in clinical practice.

• 出版日期2016
• 单位锦州医科大学