A survey of mouth level exposure to cigarette smoke in the United States

作者：Nelson Paul R^*; Chen Peter; Dixon Mike; Steichen Thomas

来源：Regulatory Toxicology and Pharmacology, 2011, 61(3): S25-S38.

DOI：10.1016/j.yrtph.2010.10.001

• Tobacco
• Smoke
• Tar
• Nicotine
• Yield
• Mouth level exposure
• Filter analysis

Smoke yields determined by a machine-based smoking method cannot adequately predict exposures experienced by human smokers. In this work, a filter analysis technique which addresses this fundamental limitation was used to measure mouth level exposures (MLE) to tar and nicotine in 1330 smokers of 26 brand-styles of US cigarettes covering a wide range of machine-generated yields.
Despite the high degree of variability observed among individual smokers, MLEs wale significantly correlated with machine-derived tar and nicotine yields (r = 0.423 for nicotine MLE/cigarette; r = 0.493 for tar MLE/cigarette; p < 0.001 for both). Mean tar and nicotine MLE was higher for males than for females. Mean MLE across races was generally similar. Menthol cigarettes tended toward lower MLE than non-menthol cigarettes and King-Size cigarettes (similar to 83 mm) tended toward lower MLE than 100's cigarettes (similar to 100 mm), though those trends were not statistically significant.
There were good agreements between MLEs measured in a group of 159 subjects smoking their usual cigarette brand-style on two separate occasions and between two independent groups of subjects smoking the same brand-styles. The results indicated that the filter analysis method used had sufficient precision to show similarity among groups.

• 出版日期2011-12-1