Alcohol-induced oxidative stress

作者：Das Subir Kumar^*; Vasudevan D M

来源：Life Sciences, 2007, 81(3): 177-187.

DOI：10.1016/j.lfs.2007.05.005

• alcohol
• ethanol
• glutathione
• hydroxy ethyl radical
• Kupffer cells
• NF-kappa B
• mitochondria
• oxidative stress
• reactive oxygen species
• reactive nitrogen species signal transduction
• tumor necrosis factor-alpha

Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). These form an environment favourable to oxidative stress. Ethanol treatment results in the depletion of GSH levels and decreases antioxidant activity. It elevates malondialdehyde (MDA), hydroxyethyl radical (HER), and hydroxynonenal (HNE) protein adducts. These cause the modification of all biological structures and consequently result in serious malfunction of cells and tissues.

• 出版日期2007-6-27
• 单位河北医科大学