Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells

作者：Wang, Wenrui; Zhang, Lingyu; Chen, Tiantian; Guo, Wen; Bao, Xunxia; Wang, Dandan; Ren, Baihui; Wang, Haifeng; Li, Yu; Wang, Yueyue; Chen, Sulian; Tang, Baoding; Yang, Qingling^*; Chen, Changjie^*

来源：Molecules, 2017, 22(11): 1814.

DOI：10.3390/molecules22111814

• solid lipid nanoparticle
• resveratrol
• breast cancer
• cyclinD1

In this study, resveratrol-loaded solid lipid nanoparticles (Res-SLNs) were successfully designed to treat MDA-MB-231 cells. The Res-SLNs were prepared using emulsification and low-temperature solidification method. The Res-SLNs were spherical, with small size, negative charge, and narrow size distribution. Compared with free resveratrol, the Res-SLNs displayed a superior ability in inhibiting the proliferation of MDA-MB-231 cells. In addition, Res-SLNs exhibited much stronger inhibitory effects on the invasion and migration of MDA-MB-231 cells. Western blot analysis revealed that Res-SLNs could promote the ratio of Bax/Bcl-2 but decreased the expression of cyclinD1 and c-Myc. These results indicate that the Res-SLN may have great potential for breast cancer treatment.

• 出版日期2017-11
• 单位蚌埠医学院