摘要
An oligodeoxynucleotide (ODN) containing a 2%26apos;,2%26apos;-difluorinated analogue of a C4%26apos;-oxidized abasic site (C4%26apos;-OAS) was designed for the amine modification of biomolecules that interact with nucleic acids. In contrast to the parent C4%26apos;-OAS, which yielded amine-modified products accompanied by DNA strand scission, the ODN containing the difluoro C4%26apos;-OAS efficiently yielded products carrying ODNs. The amine modification proceeded without additional reagents being required and might be applicable to reactions in biological systems.
- 出版日期2012-12-7