Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

作者：Wang, Biao; Wang, Yifeng^*; Jiang, Yidong; Chu, Mingming; Qi, Suosuo; Ju, Wanzhen; Xu, Danqian^*

来源：Organic and Biomolecular Chemistry, 2018, 16(41): 7702-7710.

DOI：10.1039/c8ob01943f

• CATALYTIC ENANTIOSELECTIVE FLUORINATION
• C-2-SYMMETRIC TRIDENTATE BIS(OXAZOLINE)
• OXAZOLINE-CONTAINING LIGANDS
• FRIEDEL-CRAFTS ALKYLATION
• CARBON BOND FORMATION
• DIELS-ALDER REACTION
• BETA-KETO-ESTERS
• CONTINUOUS-FLOW
• CHIRAL CATALYSTS
• RECOVERABLE CATALYSTS

A highly enantioselective fluorination of indanone-2-carboxylates catalyzed by a polystyrene-supported diphenylamine-linked bis(oxazoline) (PS-box)-Cu(OTf)(2) complex has been developed in a continuous flow system. The supported complex exhibited extremely efficient catalytic performance with high activity, affording the corresponding products in excellent yields (up to 99% yield) with excellent enantioselectivities (up to 99% ee) and more than 4000 turnover number (TON).

• 出版日期2018-11-7
• 单位浙江工业大学