Hemin-G-quadruplex-crosslinked poly-N-isopropylacrylamide hydrogel: a catalytic matrix for the deposition of conductive polyaniline

作者：Lu, Chun-Hua; Guo, Weiwei; Qi, Xiu-Juan; Neubauer, Avner; Paltiel, Yossi; Willner, Itamar^*

来源：Chemical Science, 2015, 6(11): 6659-6664.

DOI：10.1039/c5sc02203g

• DNA HYDROGEL
• FUNCTIONALIZED HYDROGELS
• PEROXIDASE-ACTIVITY
• RELEASE PROPERTIES
• PH
• APTAMER
• SENSITIVITY
• MERCURY(II)
• PROTEIN
• HYBRID

A G-rich nucleic acid-tethered acrylamide/N-isopropylacrylamide (NIPAM) copolymer is prepared. The nucleic acid-modified pNIPAM chains assemble, in the presence of K+ ions, into a stimuli-responsive G-quadruplex-crosslinked pNIPAM hydrogel undergoing cyclic and reversible solution/hydrogel/solid transitions. Addition of kryptofix [2.2.2], CP, to the K+-stabilized G-quadruplex-crosslinked hydrogel eliminates the K+ ions from the crosslinking units, resulting in the transition of the hydrogel into a pNIPAM solution. In turn, heating the pNIPAM hydrogel from 25 degrees C to 40 degrees C results in the transition of the hydrogel to the solid state, and cooling the solid to 25 degrees C restores the hydrogel state. Incorporation of hemin into the G-quadruplex-crosslinked hydrogel results in a catalytic hydrogel that catalyzes the oxidation of aniline by H2O2 to form polyaniline. The polyaniline/pNIPAM hydrogel hybrid doped with 2 M HCl forms an emeraldine salt, which exhibits an electrical conductivity of 9 x 10(-4) [cm Omega](-1).

• 出版日期2015
• 单位福州大学