Anti-VEGF Therapies in the Clinic

作者：Meadows Kellen L; Hurwitz Herbert I^*

来源：Cold Spring Harbor Perspectives in Medicine, 2012, 2(10): a006577.

DOI：10.1101/cshperspect.a006577

The development and use of antiangiogenesis agents, particularly those targeting vascular endothelial growth factor (VEGF), has become an integral component of anticancer regimens for many tumor types. This review is intended to highlight some of the most important clinical successes and failures of anti-VEGF therapies, and where possible, to suggest important lessons that have been learned. This review emphasizes data from agents that have been FDA approved and/or have completed phase III studies.

• 出版日期2012-10