A Yang-invigorating compound mixture alters neurotransmitters in rat telencephalon after exercise-induced fatigue

作者：Liu, Hongzhen^*; Zeng, Li; Kong, Xiliang; Zhu, Lei; Hou, Benhua

来源：Neural Regeneration Research, 2011, 6(15): 1158-1163.

DOI：10.3969/j.issn.1673-5374.2011.15.007

• Chinese herbal formula
• neurotransmitter
• exercise training
• exhaustive exercise
• excitability
• neural regeneration

The aim of this study was to observe the changes in monoamine and amino acid neurotransmitters in the telencephalon of rats at four functional states after exhaustive exercise and treatment with a Yang-invigorating compound recipe. The main components of this Chinese traditional medicine preparation included Radix Ginseng, Rhizoma Chuanxiong, Fructus Schisandrae, Cortex Cinnamomi, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, and Gecko. This experiment showed that dopamine (DA), 5-hydroxyindole acetic acid (5-HIAA), and gamma-aminobutyric acid levels noticeably decreased, while DA/5-hydroxytryptamine (5-HT) increased. Furthermore, glutamate (Glu) and Glu/gamma-aminobutyric acid significantly increased after 1 hour of exercise in rats in the exercise + medication group. The 5-HT and 5-HT/5-HIAA levels noticeably decreased, and DA/5-HT and Glu levels showed a robust and significant increase immediately after exhaustive exercise. The 5-HT, 5-HT/5-HIAA levels sharply decreased, while DA/5-HT, Glu and gamma-aminobutyric acid levels increased at 12 hours after exhaustion recovery. The results prove that Chinese herbal formula for strengthening Yang can induce changes in neurotransmitters in the telencephalon of rats after exhaustive exercise during the recovery process, and further improve central nervous system function.

• 出版日期2011-5-25
• 单位曲阜师范大学