Distinct function of miR-17-92 cluster in the dorsal and ventral adult hippocampal neurogenesis

作者：Jin, Junghee; Ko, Heejae; Sun, Tao^*; Kim, Seung-Nam^*

来源：Biochemical and Biophysical Research Communications, 2018, 503(3): 1594-1598.

DOI：10.1016/j.bbrc.2018.07.086

• miR-17-92 cluster
• Distinct function
• Hippocampus
• Regional expression
• Dentate gyrus

It has been known that the dorsal and ventral areas of the dentate gyrus in the hippocampus have distinct roles in memory and mood behaviors. We previously reported that microRNA miR-17-92 regulates adult hippocampal neurogenesis and mood disorders. Here, we suggest that the miR-17-92 cluster is highly expressed in the ventral than the dorsal dentate gyrus in the adult mouse hippocampus. Deletion of mi R-17-92 in the adult hippocampus only affects development of neural progenitors in the ventral dentate gyrus, and miR-17-92 knockout mice have no defects in memory functions. Our results suggest that regional expression of miR-17-92 in the dentate gyrus is associated with their distinct functions in hippocampal neurogenesis and related behaviors.

• 出版日期2018-9-10
• 单位华侨大学