Antinuclear antibodies testing as a routine screening for systemic lupus erythematosus in patients presenting first-episode psychosis

作者：Mantovani Celia; Louzada Junior Paulo; Nunes Emerson Arcoverde; de Figueiredo Felipe Pinheiro; Oliveira Clicio Reboucas; Del Ben Cristina Marta

来源：Early Intervention in Psychiatry, 2012, 6(3): 322-325.

DOI：10.1111/j.1751-7893.2011.00339.x

• antinuclear antibodies
• differential diagnosis
• early onset psychosis
• first-episode psychosis
• systemic lupus erythematosus

Aims: This report discusses the use of antinuclear antibody (ANA) detection as a screening test for neuropsychiatry systemic lupus erythematosus (NPSLE) in patients presenting a first-episode psychosis. Methods: We reviewed the medical records of 85 patients admitted to an emergency service due to first-episode psychosis, during a 1-year period, for whom ANA detection was performed through an IFI HEp2 cell assay. ANA-positive patients were subsequently evaluated for autoantibodies and neuroimaging exams. Results: Three patients presented as ANA positive in the initial screening and further investigation confirmed NPSLE in two patients. The patients were treated with antipsychotics and cyclophosphamide pulses with satisfactory outcomes. Conclusion: Even though ANA detection is not specific, it is a low-cost procedure and could be an important screening test for NPSLE in the early-onset psychosis.

• 出版日期2012-8