Mixed Gold-Silver Clusters Possessing N-Heterocyclic Carbenes: Synthesis, Structural Characterization, and Cytotoxicity

作者：Chen Chao; Qiu Hua-Yu^*; Liu Ai-Ling; Chen Dan; Tang Gu-Ping; Chen Wan-Zhi

来源：Chinese Journal of Inorganic Chemistry, 2011, 27(7): 1423-1430.

• gold
• silver
• cluster
• N-heterocyclic carbene
• cytotoxicity

Gold and silver clusters, [Au(2)AgL(2)(CH(3)CN)(2)](PF(6))(3) (2, L=bis(N-pyridylimidazoliumyl)methane) and [Au(4)AgL(4)](PF(6))(5) (3), have been synthesized from [Ag(3)L(2)(CH(3)CN)(2)](PF(6))(3) (1) via transmetallation reactions, and their structures were determined by X-ray diffraction analysis. Complexes 1 and 2 are isostructural with each other consisting of triangular metallic rings showing weak metal-metal interaction. Complex 3 is a chain compound with the silver atom located in between two Au(2) units. All the complexes are luminescent in their solid states at room temperature. The cytotoxicities of the complexes were investigated by MTT assay. The results show that all these complexes are toxic to HuH7, C6, and A375 tumor cells, and the toxicity order is 1 > 2 > 3 consistent with the silver content in these complexes. CCDC: 724081, 2; 724083, 3.

• 出版日期2011-7
• 单位杭州师范大学