Unified Syntheses of Cavicularin and Riccardin C: Addressing the Synthesis of an Arene Adopting a Boat Configuration

作者：Kostiuk Sarah L; Woodcock Timothy; Dudin Leo F; Howes Peter D; Harrowven David C^*

来源：Chemistry - A European Journal, 2011, 17(39): 10906-10915.

DOI：10.1002/chem.201101550

• natural products
• radical reactions
• strained molecules
• synthetic methods
• total synthesis

Concise syntheses of the natural products cavicularin (ten steps) and riccardin C (seven steps) are reported. Key features of the new synthetic route are a convergent strategy to assemble acyclic precursors and a sequence of regioselective reduction and halogenation steps to facilitate Wittig macrocyclisation and transannular ring contraction reactions.

• 出版日期2011-9