A role for anti-transglutaminase 2 autoantibodies in the pathogenesis of coeliac disease?

作者：Lindfors K; Kaukinen K; Maki M^*

来源：Amino Acids, 2009, 36(4): 685-691.

DOI：10.1007/s00726-008-0127-5

• Coeliac disease
• Transglutaminase 2
• Autoantibodies
• Pathogenesis

Coeliac disease is an autoimmune-mediated disorder with both innate and adaptive immune components. The disease is triggered by dietary gluten, which provokes the development of a massive immune reaction leading to the destruction of the small-intestinal mucosal morphology and intestinal dysfunction. Besides the typical small-bowel symptoms extraintestinal manifestations may also arise in a subset of coeliac disease patients. In addition, gluten evokes the production of antibodies mainly targeting deamidated gluten peptides or transglutaminase 2. Although coeliac disease has traditionally been regarded as a T cell-mediated disorder, this review discusses the role of the gluten-induced disease-specific anti-transglutaminase 2-autoantibodies in the pathogenesis of the disease.

• 出版日期2009-4