A general and efficient synthesis of 5,6-dihydrodibenzo[b,h] [1,6]naphthyridine derivatives

作者：Dobrowolski Jeremy C; Katen Alice; Fraser Benjamin H; Bhadbhade Mohan; Black David Stc; Kumar Naresh^*

来源：Tetrahedron Letters, 2016, 57(49): 5442-5445.

DOI：10.1016/j.tetlet.2016.10.067

• Dihydroquinolin-4-one
• Dihydrodibenzo[b,h][1,6]naphthyridines
• Acid-catalyzed synthesis

A two-step procedure for the synthesis of dihydrodibenzonaphthyridine derivatives from benzaldehydes and 2-aminoacetophenones, proceeding through a substituted dihydroquinolone intermediate, is described. The synthetic protocol allows for a versatile and robust coupling method between a range of 2-aminoacetophenones or 2-aminobenzophenones and a selection of substituted dihydroquinolones.

• 出版日期2016-12-7