科研之友
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摘要
A silver(I)-mediated base pair based on azole-derived ligands only was devised. The base pair comprises the monodentate imidazole nucleoside and a nucleoside carrying the new bidentate ligand 4-[(1H-1,2,4-triazol-1-yl)methyl]-1H-1,2,3-triazole. The silver(I) ion is hence coordinated in a trigonal planar [2+1] environment. A representative DNA duplex comprising the new base pair is stabilized by 6 degrees C upon binding one equivalent of silver(I). CD spectroscopy was used to confirm that the duplex adopts the canonical B-type conformation. The base pair represents the first example of a metal-mediated base pair with a [2+1] coordination environment.
- 出版日期2014-1
