Assessment of Oxidative Stress in Patients with an Isolated Traumatic Brain Injury Using Disposable Electrochemical Test Strips

作者：Rael Leonard T; Bar Or Raphael; Kelly Michael T; Carrick Matthew M; Bar Or David^*

来源：Electroanalysis, 2015, 27(11): 2567-2573.

DOI：10.1002/elan.201500178

• Isolated traumatic brain injury
• Oxidative stress
• Human plasma
• Redox chemistry
• Sensors

The barriers to using plasma redox potential as a measure of oxidative stress in patients are the use of specialized equipment, necessity of sterilization between tests, and inconsistent electrode surfaces and cell geometry. These problems are resolved using disposable test strips with built in electrochemical cells. Measuring the electrode potential at a small current yields a stable value that is similar to 50 mV higher for isolated traumatic brain injury (ITBI) patients than for healthy individuals. Even with natural variations within blood chemistry, this simple method may be clinically useful for assessing the degree of oxidative stress and injury severity in ITBI patients.

• 出版日期2015-11