A NusG-like transcription anti-terminator is involved in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus

作者：Paitan Y; Orr E; Ron EZ; Rosenberg E^*

来源：FEMS Microbiology Letters, 1999, 170(1): 221-227.

DOI：10.1111/j.1574-6968.1999.tb13377.x

• Myxococcus xanthus
• antibiotic biosynthesis
• type I polyketide synthase
• polyketide
• NusG
• transcription anti-termination

The antibiotic TA of Myxococcus xanthus is synthesized through a type I polyketide synthase mechanism. Previous studies have indicated that several genes essential for TA production are clustered within a 40-kb region and are transcriptionally co-regulated. In this study, we report the genetic analysis of the first gene in the TA gene cluster, identified as a NusG-like transcription anti-terminator. Functional analysis of this NusG-like anti-terminator gene by specific gene disruption confirms that it is essential for TA production bur not for normal growth and development.

• 出版日期1999-1-1